Human N-methyl-D-aspartate receptor subunits, nucl

专利名称：Human N-methyl-D-aspartate receptor

subunits, nucleic acids encoding same anduses therefor

发明人：Lorrie P. Daggett,Chin-Chun Lu申请号：US10007747申请日：20011207

公开号：US20020161193A1公开日：20021031

摘要：In accordance with the present invention, there are provided nucleic acidsencoding human NMDA receptor protein subunits and the proteins encoded thereby.The NMDA receptor subunits of the invention comprise components of NMDA receptorsthat have cation-selective channels and bind glutamate and NMDA. In one aspect of theinvention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDAreceptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1,NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. Inaddition to being useful for the production of NMDA receptor subunit proteins, thesenucleic acids are also useful as probes, thus enabling those skilled in the art, withoutundue experimentation, to identify and isolate related human receptor subunits.Functional glutamate receptors can be assembled, in accordance with the presentinvention, from a plurality of one type of NMDA receptor subunit protein (homomeric) orfrom a mixture of two or more types of subunit proteins (heteromeric). In addition todisclosing novel NMDA receptor protein subunits, the present invention also comprisesmethods for using such receptor subunits to identify and characterize compounds which

affect the function of such receptors, e.g., agonists, antagonists, and modulators ofglutamate receptor function. The invention also comprises methods for determiningwhether unknown protein(s) are functional as NMDA receptor subunits.

申请人：DAGGETT LORRIE P.,LU CHIN-CHUN

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