STRUCTURE-BASED DRUG DESIGN METHODS FOR IDENTIFYIN

专利名称：STRUCTURE-BASED DRUG DESIGN

METHODS FOR IDENTIFYING D-ALA-D-ALALIGASE INHIBITORS AS ANTIBACTERIALDRUGS

发明人：NAVIA, Manuel, A.,ALA, Paul, J.,GRIFFITH,

James, P.,ALI, Janid, A.,FAERMAN, Carlos,H.,MOE, Scott, T.,MAGEE, Andrew,

S.,CONNELLY, Patrick, R.,PEROLA, Emanuele

申请号：EP02749688.4申请日：20020628公开号：EP1412516A2公开日：20040428

摘要：The present invention is based on such discovery,I.e. certain small molecules canbe with ATP binding site D-Ala-D-Ala ligases, even if in the substrate without the enzymeand conformation change enzymatic structure can be caused to be similar to thosegenerations and combining ATP and substrate and enzyme. It is without wishing to bebound to any theory, it is believed that this conformation change is to activate or inhibitthe enzyme. The interaction in critical active site, and design and optimization inhibitorhave been identified from discovery information obtained.

申请人：Essential Therapeutics, Inc.,PLIVA D.D.

地址：1365 Main Street Waltham, MA 02451-1624 US,Ulica grada Bukovara 49 10000Zagreb HR

国籍：US,HR

代理机构：Schrell, Andreas, Dr.

更多信息请下载全文后查看