Inhibitor of Endogenous Human Interferon-Gamma

专利名称：Inhibitor of Endogenous Human Interferon-Gamma

发明人：Ivan Ivanov,Rumen Tsanev,Genoveva

Nacheva,Hans-Guenther Grigoleit,RolfGunther

申请号：US11886853申请日：20051005

公开号：US20090208452A1公开日：20090820

专利附图：

摘要：The invention relates to an inhibitor of endogenous human interferon-gamma(hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, theinvention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity tothe hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝwhere the C-terminal part of the molecule is either deleted or replaced with a

polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated byphysical or chemical methods.

申请人：Ivan Ivanov,Rumen Tsanev,Genoveva Nacheva,Hans-Guenther Grigoleit,RolfGunther

地址：Sofia BG,Sofia BG,Sofia BG,Wiesbaden DE,Mainz DE

国籍：BG,BG,BG,DE,DE

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